2020.9-至今
温州医科大学
公共卫生与管理学院
研究员(教授)/博士生导师/二层次引进人才“学科带头人”
2010.3-2020.8
中国科学院近代物理研究所
研究员
2009.2-2010.2
美国德州大学西南医学中心放射分子生物学研究中心
博士后
2005.11-2009.1
美国哥伦比亚大学辐射研究中心
博士后
2001.9-2005.6
中国科学院合肥物质科学研究院核能科学与工程专业
博士研究生
1998.9-2001.6
安徽农业大学预防兽医学专业
硕士研究生
1994.7-1998.8
合肥南方鸡场
历任技术员、防疫室主任、分场副场长
1990.9-1994.6
安徽农学院兽医专业
学士
研究项目
1. 温州医科大学人才科研启动项目,89220012,2020/09-2025/09,300万元,主持。
2. HIRFL用户培育项目,Y9HIRFL200,2019/06-2020/06,10万元,主持。
3. 国家重点研发专项子课题,2017YFCO1O8605,2017/07-2019/12,460万元(国拔230万元),项目书实际撰写人与子任务负责人(获配国拔经费120万元)。
4. 国家自然科学基金重点项目,11635013,载能粒子辐射生物效应的理化基础及早期生物过程研究,2017/01-2021/12,直接经费300万元,课题负责人(获拔经费120万元)。
5. 国家自然科学基金联合基金培育项目,U1432121,赖氨酸甲基转移酶SET8调控对肿瘤细胞重离子辐射敏感性的影响及其机制研究,2015/01-2017/12,66万元,主持。
6. 国家重大传染病防治专项项目子任务,2014ZX10004002-004-002,呼吸道上皮细胞立体培养平台的构建及应用,2014/1-2016/12,74.01万元,主持。
7. 国家重大科学仪器设备开发专项项目子任务,2012YQ03014210,高能质子辐照器官样组织的研究,2012/10-2017/9,20万元,主持。
8. 国家自然科学基金面上项目,31170803,肿瘤干细胞产生与重离子辐射相关性研究,2012/01-2015/12,60万元,主持。
9. 中科院“西部引杰”+“百人计划”项目,2010/03-2014/03,360万元,主持。
10. 科技部国家重点基础研究发展计划(973计划)项目,2010CB834201,重离子治癌关键科学技术问题研究:子课题“重离子治癌机理研究”,2010/01-2014/10,973万元,参与(获配经费80万元)。
科学研究
1. Du Y, Pan D, Jia R, Chen Y, Wang J, Hu B*. The reduced oligomerization of MAVS mediated by ROS enhances the cellular radioresistance. Oxidative Medicine and Cellular Longevity. 2020; DOI:10.1155/2020/2167129.(*corresponding author)
2. Li XM, Tan Y, Huang CQ, Xu MC, Li Q, Pan D, Zhao BQ*, Hu BR*. MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation. Biomed Environ Sci. 2018;31(6):467-472.
3. Chen YX, Xie GC, Pan D, Du YR, Pang LL, Song JD, Duan ZJ, Hu BR*. Three-dimensional Culture of Human Airway Epithelium in Matrigel for Evaluation of Human Rhinovirus C and Bocavirus Infections. Biomed Environ Sci. 2018;31(2):136-145.
4. Li X, Zha X, Wang Y, Jia R, Hu B*, Zhao B*. Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development .Chemosphere. 2018;200:302-312.
5. Chen Y, Pan D, Du Y, Jia R, Li X, Hu B*. Induction of cancer stem-like cells in A549 cells after exposure to carbon ions and X-rays. Int. J. Radiat. Res., 2019, 17(1): 25-35.
6. 贾蓉,苏锋涛,胡步荣. 重离子的辐射生物效应及其在生命科学中的应用. 《生物技术通报》,2018; 34(1):67-78.
7. Burong Hu*, Dong Pan. DNA/RNA Methylation Alterations in Cancer Cells. eBook. OMICS international. 2017. doi:10.4172/978-1-63278-007-2-008.
8. Xiaoman Li , Dehui Ma, Xiaodan Zha, Dongqin Quan, Dong Pan, Manji Sun, Burong Hu*, Baoquan Zhao*. Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by γ-ray irradiation in mice. Oncotarget. 2017, 8(37): 60789–60808.
9. Sun M, Pan D, Chen Y, Li Y, Gao K*, Hu B*. Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway. Oncotarget. 2017, 8(20): 32807-32820.
10. Pan D, Chen Y, Du Y, Ren Z, Li X, Hu B*. Methylation of promoter of RBL1 enhances the radioresistance of three dimensional cultured carcinoma cells. Oncotarget. 2017, 8(3):4422-4435.
11. Pan D, Du Y, Ren Z, Chen Y, Li X, Wang J, Hu B*. Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells. Oncotarget. 2016, 7(37):60432-60445.
12. DU YR, Pan D, Chen YX, Xue G, Ren ZX, Li XM, Zhang SC, Hu BR*. Irradiation Response of Adipose-derived Stem Cells under Three-dimensional Culture Condition. Biomed Environ Sci. 2015, 28(8):549-557.
13. Xue G, Ren Z, Chen Y, Zhu J, Du Y, Pan D, Li X, Hu B*. A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation, Cancer Letters, 2015, 361(1):121-127.
14. Xue G, Ren Z, Grabham PW, Chen Y, Zhu J, Du Y, Pan D, Li X, Hu B*. Reprogramming Mediated Radioresistance of Three-dimensional Grown Cancer Cells. J Radiat Res. 2015, 56(4):656-662.
15. Zhao DG, Chen JJ, Du YR, Ma YY, Chen YX, Gao K* and Hu BR*. Synthesis and structure-activity relationships of N-methyl-5,6,7-trimethoxylindoles as novel antimitotic and vascular disrupting agents. Journal of Medicinal Chemistry, 2013;56(4):1467-1477.
16. Hu B*, Zhu J, Zhou H, Hei TK. No significant level of inheritable interchromosomal aberrations in the progeny of bystander primary human fibroblasts after alpha particle irradiation. Advances in Space Research, 2013,51(3). 450-457.
17. Hu B*, Grabham PW, Nie J, Balajee AS, Zhou H, Hei TK, and Geard CR*. Intrachromosomal changes and genomic instability in site-specific microbeam irradiated and bystander human-hamster hybrid cells. Radiation Research, 2012;177(1):25-34.
18. Aroumougame A, Hu B and Chen DJ. Unrepaired Clustered DNA Lesions Induced Chromosome Breakage in Human Cells. PNAS. 2011;108(20):8293-8.
19. Aroumougame A, Hu B, Delgado O, Ding L,Story M, Minna J, Shay J and Chen DJ. Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture. Nucleic Acids Research. 2011;39(13):5474-88.
20. Grabham PW, Hu B, Sharma P, Geard CR. Effects of ionizing radiation on three-dimensional human vessel models: differential effects according to radiation quality and cellular development. Radiat Res. 2011;175(1):21-8.
21. Hu B, Shen B, Su Y, Geard CR and Balajee AS. Protein Kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. The International Journal of Biochemistry & Cell Biology. 2009, 41(12): 2413-21.
22. Hu B, Wu L, Han W, Zhang L, Xu A, Hei TK, Yu Z. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis. 2006, 27(2):245-251
23. Hu B, Han W, Wu L, Feng H, Liu X, Zhang L, Xu A, Hei TK, Yu Z. In Situ Visualization of DSBs to Assess the Extranuclear/Extracellular Effects Induced by Low Dose a-particle Irradiation. Radiat Res. 2005, 164(3):286-291