1990.9-1995.7
哈尔滨医科大学预防医学专业
医学学士
1995.9-1998.7
白求恩医科大学卫生毒理学专业
医学硕士
1998.7-2000.9
白求恩医科大学预防医学院
助教
1999.9-2002.7
吉林大学白求恩医学部放射医学专业
医学博士
2000.9-2004.9
吉林大学公共卫生学院
讲师
2002.10-2004.10
东北师范大学细胞与遗传研究所生物学专业
博士后
2003.2-2004.3
加拿大曼尼托巴大学医学院免疫学专业
博士后
2004.12-2007.12
吉林大学公共卫生学院
副教授/副院长
2005.11-2006.11
美国哈佛大学公共卫生学院遗传和复杂疾病系放射生物学专业
博士后
2007.12-2017.06
吉林大学公共卫生学院
教授/博士生导师/副院长
2015.3-2015.9
美国哥伦比亚大学医学院辐射研究中心
访问学者
2018年6月-至今
温州医科大学公共卫生与管理学院
教授/博士生导师/院长
研究项目
1. 国家重点研发计划“数字诊疗装备研发”重点专项(2017YFC0108602,458万元):光子放疗生物学效应评估技术研究,2017-2019,课题负责人(The National Key Research and Development Program of China)
2. 教育部新世纪优秀人才支持计划(NCET-09-0424,50万):辐射诱导肿瘤细胞自噬性死亡的非编码调控及表观遗传学调控,2009-2012,负责人
3. 国家自然科学基金项目(81972969, 55万):电离辐射诱导PRMT5发生选择性剪接的调控机制与辐射敏感性,2020-2023,负责人
4. 国家自然科学基金项目(81773363, 72万):蛋白质精氨酸甲基转移酶5的选择性剪切子PRMT5S在辐射损伤及细胞死亡中的作用及调控机制,2018-2021,负责人
5. 国家自然科学基金项目(81573082, 84万):电离辐射作用后溶酶体介导的细胞死亡机制研究,2016-2019,负责人
6. 国家自然科学基金项目(31370837, 80万):dCK与Cdk1相互作用对辐射诱导的细胞周期G2/M期检查点激活的调控机制,2014-2017,第二负责人
7. 国家自然科学基金项目(30970682, 30万):MicroRNA在电离辐射诱导的肿瘤细胞自噬性死亡中的作用及其表观遗传学调控;2010-2012,负责人
8. 国家自然科学基金项目(30770649, 31万):电离辐射诱导肿瘤细胞自噬性死亡机制的研究;2008-2010,负责人
9. 国家自然科学基金项目(30500142, 23万):RNA干预(RNAi)联合放射治疗p53第八外显子肿瘤相关性杂合突变研究;2006-2008,负责人
10. 国家重点基础研究发展规划项目(973项目,2011CB503706,100万):电磁辐射危害健康的机理及医学防护的基础研究,2010-2014,分课题负责人
11. 国家重点基础研究发展规划项目(973项目,2009CB930102,60万):纳米生物材料合成、组装及在生物领域的应用,2009-2013,分课题参加人
12. 国家高校博士点基金项目(20100061110070,6万): 分割剂量放疗联合p53突变子基因治疗逆转肿瘤多药耐药实验研究,2010-2012,负责人(Research Fund for the Doctoral Program of Higher Education of China)
13. 国家人口与健康科学数据共享服务平台肿瘤专题服务数据购置与共享(NCMI-ABS03-201709-02,20万元),2018年-2020
科学研究
1. Wu B, Wang H, Zhang L, Sun C, Li H, Jiang C, Liu X. High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression. Biomed Pharmacother. 2019 Apr;112:108555. doi: 10.1016/j.biopha.2019.01.016.
2. Liang N, He Q, Liu X, Sun H. Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy. Cell Biochem Funct. 2019 Apr;37(3):177-184. doi: 10.1002/cbf.3385
3. Dan Shi, Zhenzhen Liang, Cheng Zhang, Huaiyu Zhang and Xiaodong Liu.The effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/ chemoradiotherapy: a meta-analysis. BMC Cancer (2018) 18:308-317 doi.org/10.1186/s12885-018-4232-x
4. Dan Shi, Cheng Zhang, Xiaodong Liu. Long noncoding RNAs in cervical cancer. J Can Res Ther. 2018, 14: 745-753
5. Zhong R, Liang B, Xin R, Zhu X, Liu Z, Chen Q, Hou Y, Jin Z, Qi M, Ma S, Liu X. Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells. Int J Oncol. 2018 Mar;52(3):1000-1010. doi: 10.3892/ijo.2018.4250
6. Dandan Zhou, Xiufen Liu, Chengwei Liu, Om Prakash Pant, xiaodong Liu. Long non-coding RNA PVT1: emerging biomarker in digestive system cancer. Cell Prolif., 2017 Dec;50(6). doi: 10.1111/cpr.12398.
7. Rui Zhong, Rui Xin, Zongyan Chen, Nan Liang, Yang Liu, Shumei Ma,* and Xiaodong Liu.* The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death。Int. J. Mol. Sci. 2016, 17, 1939; doi:10.3390/ijms17111939
8. Li Cui, Zhiheng Song, Bing Liang, Lili Jia, Shumei Ma, Xiaodong Liu. Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells. Oncology Reports. Apr 2016 ,35:3639-3647
,.
9. Zongyan Chen, Xiaodong Liu, Shumei Ma. The Roles of Mitochondria in Autophagic Cell Death. Cancer Biother.Radiophaem., 2016, OCT 31(8):269-276
10. Bing Liang, Xiaodong Liu, Yang Liu, Dejuan Kong, Xiaomei Liu, Rui Zhong, Shumei Ma. Inhibition of autophagy sensitizes MDR-phenotype ovarian cancer SKVCR cells to chemotherapy. Biomedicine & Pharmacotherapy. 2016, 82:98-105
11. Xin Liu, Shuang Li, Xuejun Lin, Kangkang Yan, Longyu Zhao, Qiong Yu, Xiaodong Liu. AXIN2 is Associated With Papillary Thyroid Carcinoma, Iran Red Crescent Med J. 2016 Jan 1;18(2):e20960
12. Wang B, Chen Z, Yu F, Chen Q, Tian Y, Ma S, Wang T, Liu X. Hsp90 regulates autophagy and plays a role in cancer therapy. Tumour Biol. 2016 Jan;37(1):1-6
13. Zongyan Chen, Benli Wang, Feifei Yu, Qiao Chen, Yuxi Tian, Shumei Ma, Xiaodong Liu. The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells. Tumor Biol. 2016 Mar;37(3):4083-91
14. Yu F, Chen Z, Wang B, Jin Z, Hou Y, Ma S, Liu X. The role of lysosome in cell death regulation. Tumour Biol. 2016 Feb;37(2):1427-36
15. Nan Liang, Rui Zhong, Xue Hou, Gang Zhao, Shumei Ma, Guanghui Cheng, Xiaodong Liu.ATM participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells. Cell Prolif., 2015, 48, 561–572
16. Zhong R, Xu H, Chen G, Zhao G, Gao Y, Liu X, Ma S, Dong L. The role of hypoxia-inducible factor-1α in radiation-induced autophagic cell death in breast cancer cells. Tumor Biol. 2015 Sep;36(9):7077-83.
17. He M, Zhao Y, Yi H, Sun H, Liu X, Ma S. The combination of TP53INP1, TP53INP2 and AXIN2: potential biomarkers in papillary thyroid carcinoma. Endocrine. 2015 Mar;48(2):712-7
18. Zhao Y, Zhong R, Sun L, Jia J, Ma S, Liu X. Ionizing Radiation-Induced Adaptive Response in Fibroblasts under Both Monolayer and 3-Dimensional Conditions. PLoS One. 2015 Mar 25;10(3):e0121289. 3.53
19. Liu M, Liu B, Wang H, Ding L, Shi Y, Ge C, Su X, Liu X, Dong L.Dosimetric comparative study of 3 different postoperative radiotherapy techniques (3D-CRT, IMRT, and RapidArc) for II-III stage rectal cancer. Medicine . 2015 Jan;94(1):e372. 4.87
20. Zhao YL, Zhong LL, He MZ, Chen SL, Wang TJ, Ma SM, Liu XD. The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma. Int J Mol Med. 2015 Oct;36(4):1097-103
21. Chen S, Liu X, Ma S .Combination of miRNA and RNA Functions as Potential Biomarkers for Gastric Cancer .Tumour Biol., 2015 Dec;36(12):9909-18.
22. Cong Dan, He Mengzi, chen Silin, Liu xiaoli, Liu Xiaodong, Sun Hui. Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas. OncoTargets and Therapy 2015:8 2271–2277
23. Yan KK, Xu XJ, Liu XD, Wang CP, Liu X. The associations between maternal factors during pregnancy and the risk of childhood acute lymphoblastic leukemia: A meta-analysis. Pediatric Blood & Cancer, 2015 Mar1, DOI:10.1002/pbc.25443
24. Li S, Wang C, Liu X, Hua S, Liu X. The roles of AXIN2 in tumorigenesis and epigenetic regulation. Fam Cancer. 2015 Jun;14(2):325-31